To be fair Twente isn't as bad as you might think, but could be not great either, I am not entirely sure. I would give Lazio a chance to win of course, but I wouldn't consider Twente to do nothing neither, they may try their best and possibly do something this game too. This is why I have hopes about them having a chance of getting at least a draw.
Europa has been quite complicated so far, I am not sure who will win against who, betting on it is very tough, hell even UCL has been tough and making me lose, so I can't say European competitions are great this season. I haven't checked conference league to be fair, I am not going to lie I don't know what's going on there, maybe it's easier to gamble there, but for these two competitions things are tough.
If you compare these two teams, Lazio is better, but as you said Twente is not as bad as imagined. When they can be in the European League, you should be able to see that they are not an ordinary team, but when compared to names like Lazio, they are still slightly below Lazio. However, in the European League like this, this is not a guarantee, because there are many surprises that occur, especially Twente will definitely try their best to do their best. If you look at it at a glance, then I will not deny that I will choose the team that is stronger on paper, that is the easiest way to bet. However, in football it is not that simple, there are many factors that can make a team win a match, luck for example.