To be fair Twente isn't as bad as you might think, but could be not great either, I am not entirely sure. I would give Lazio a chance to win of course, but I wouldn't consider Twente to do nothing neither, they may try their best and possibly do something this game too. This is why I have hopes about them having a chance of getting at least a draw.
Europa has been quite complicated so far, I am not sure who will win against who, betting on it is very tough, hell even UCL has been tough and making me lose, so I can't say European competitions are great this season. I haven't checked conference league to be fair, I am not going to lie I don't know what's going on there, maybe it's easier to gamble there, but for these two competitions things are tough.
People do not consider Twente to lose for sure neither, Lazio doesn't have like 1.40 odds or anything like that, they have 2.20 odds in most places. Meaning, while Lazio is the favourite to win, having 2.20 means they are not really high favourites or going to dominate, anything could happen. This is why we need to make sure we are dealing with a period where it is going to take some time for us to learn who will win.
There are some easier games, betting on them looks like it would be smarter, Galatasaray should be able to beat Elfsborg, Frankfurt should be beating RFS, Ajax should beat Qarabag, Nice should beat Frencvaros, these are games that I think should be easier to bet and we would make more profit from these games.