Every team in the European League is almost equal, so competition is always high in the European League. Even if the big team can separate here, it cannot be said that the big team will win the title in the end. Liverpool were probably the biggest team in the Europa League last season and everyone was saying that Liverpool would win the Europa League title last season but Liverpool couldn't do it. Far from winning the title, they exited the tournament before qualifying for the semi-finals.
Like last season, Manchester United is considered as a worthy contender to win the title this season but Manchester United may not be able to win the Europa League title.
Maybe we'll see another team win the Europa League title.
Nobody can predict what will happen on the field. Last season Liverpool came into the UEL as favourites, they managed to win every game before Atalanta stopped them. This season there will be a new champion in UEL, Lazio is the most consistent team so far, but that doesn't mean they can win the trophy at the end of the competition.
I don't think Man United are capable of competing in the title race, just look at their performance in the EPL, they always get minor results even though the opponents they face are not too strong.
Every competition will always have unexpected surprises, especially when entering the knockout stage, whether in the UCL, Europe, or the European conference league, there are always surprises. Teams that appear consistently during the group stage or now with a new format will not guarantee smoothness when entering the knockout stage.
Examples like last season Liverpool and even Leverkusen that you mentioned. Liverpool last season were very favored to win the title because besides having a strong squad they also had experience in the competition, especially when they lost to Man City in the EPL trophy, only the European league was their only hope but who would have thought they lost to Atalanta.
And not only that after Liverpool failed, many people predicted that Leverkusen would be champions because their performance was very impressive even without losing throughout the season but who would have thought they also lost to Atalanta in the last match even that was one of Leverkusen's defeats. This season will also be like that, every team has the same opportunity to win the European league title, it is not impossible for Man United. Even though they are very down in the EPL, who would have thought that Amorim's strategy is that he only wants to show his abilities and wants to focus fully on the European league. So for now it is very difficult to favor one team because every team has the same chance.