If crypto casinos, or casinos in general weren't profitable, there wouldn't be so many of them, haha.
You're right, the house always wins and there won't be any other competitors coming in if this industry isn't profitable.
But that's how it goes in our minds and in reality, it's not too easy to be known into this industry and that's why every promos are also being taken care and thought of by the casino that shall be bitten by many users to be attractive.
Sure, there's an odd winner that flashes he just 100x his wager, but in general, house always wins
Reputable casinos do this as an extended way of promotion but this is happening for real and if someone made 100x wager his wager, it's nothing compared to how much the house have won.