G-protein
https://en.wikipedia.org/wiki/Vasopressin_receptor_1A
https://en.wikipedia.org/wiki/G_protein
GαsEdit
Gαs activates the cAMP-dependent pathway by stimulating the production of cyclic AMP (cAMP) from ATP. This is accomplished by direct stimulation of the membrane-associated enzyme adenylate cyclase. cAMP can then act as a second messenger that goes on to interact with and activate protein kinase A (PKA). PKA can phosphorylate a myriad downstream targets.
The cAMP-dependent pathway is used as a signal transduction pathway for many hormones including:
ADH – Promotes water retention by the kidneys (created by the magnocellular neurosecretory cells of the posterior pituitary)GHRH – Stimulates the synthesis and release of GH (somatotropic cells of the anterior pituitary)GHIH – Inhibits the synthesis and release of GH (somatotropic cells of anterior pituitary)CRH – Stimulates the synthesis and release of ACTH (anterior pituitary)ACTH – Stimulates the synthesis and release of cortisol (zona fasciculata of the adrenal cortex in the adrenal glands)TSH – Stimulates the synthesis and release of a majority of T4 (thyroid gland)LH – Stimulates follicular maturation and ovulation in women; or testosterone production and spermatogenesis in menFSH – Stimulates follicular development in women; or spermatogenesis in menPTH – Increases blood calcium levels. This is accomplished via the parathyroid hormone 1 receptor (PTH1) in the kidneys and bones, or via the parathyroid hormone 2 receptor (PTH2) in the central nervous system and brain, as well as the bones and kidneys.Calcitonin – Decreases blood calcium levels (via the calcitonin receptor in the intestines, bones, kidneys, and brain)Glucagon – Stimulates glycogen breakdown in the liverhCG – Promotes cellular differentiation, and is potentially involved in apoptosis.[21]Epinephrine – released by the adrenal medulla during the fasting state, when body is under metabolic duress. It stimulates glycogenolysis, in addition to the actions of glucagon.GαiEdit
Gαi inhibits the production of cAMP from ATP. eg. somatostatin,prostaglandins
Gαq/11Edit
Gαq/11 stimulates the membrane-bound phospholipase C beta, which then cleaves PIP2 (a minor membrane phosphoinositol) into two second messengers, IP3 and diacylglycerol (DAG). The Inositol Phospholipid Dependent Pathway is used as a signal transduction pathway for many hormones including:
ADH (Vasopressin/AVP) – Induces the synthesis and release of glucocorticoids (Zona fasciculata of adrenal cortex in kidney); Induces vasoconstriction (V1 Cells of Posterior pituitary)TRH – Induces the synthesis and release of TSH (Anterior pituitary)TSH – Induces the synthesis and release of a small amount of T4 (Thyroid Gland)Angiotensin II – Induces Aldosterone synthesis and release (zona glomerulosa of adrenal cortex in kidney)GnRH – Induces the synthesis and release of FSH and LH (Anterior Pituitary)Gα12/13EditGα12/13 are involved in Rho family GTPase signaling (see Rho family of GTPases). This is through the RhoGEF superfamily involving the RhoGEF domain of the proteins' structures). These are involved in control of cell cytoskeleton remodeling, and thus in regulating cell migration.GβEditThe Gβγ complexes sometimes also have active functions. Examples include coupling to and activating G protein-coupled inwardly-rectifying potassium channels.
Hlm ok
Still its mostly empirical study
In a study of 203 male and female university students, participants with short (308-325 bp) vs. long (327-342) versions of RS3 were less generous, as measured by lower scores on both money allocations in the dictator game, as well as by self-report with the Bardi-Schwartz Universalism and Benevolence Value-expressive Behavior Scales; although the precise functional significance of longer AVPR1A RS3 repeats is not known, they are associated with higher AVPR1A postmortem hippocampal mRNA levels.[9]
The brain is not a mathematical theorem.
