Two of the 49ers' four losses this season have come against dual-threat QBs, QBs who can run the ball well: Fields in Week 1 and Mariota in Week 6. I know it was early in the season and under different circumstances, but still... The 49ers have the league's best run defense, but they'll have their hands full with Hurts' ability to run and his designed Redzone runs, which are difficult to defend/scheme against.
I also like AJ Brown's matchup against the 49ers' secondary, which i believe is their weakest link. Metcalf played well on the outside in the wild-card game.
Purdy vs. Eagles pass rush is also something to watch, Cowboys' defense was Purdy's first real test, and despite not throwing a touchdown, he didn't give the ball away either, no turnovers. The Eagles' pass rush ranks second in pressure rate and first in sacks, making this another difficult matchup for him.
I got the Eagles and Bengals making it to the owl. Excited to watch both games...