Please can we stop these 'Did x deliberately create covid-19' threads? Or can we at least proceed by means of evidence rather than baseless conspiracy theories? Conspiracy theories are nonsense unless they stand on evidence. Data overrules blind supposition every time. It seems kind of ridiculous to say a) Bill Gates warned against a future pandemic and said we are not ready for it, and b) Bill Gates warned that the world population is too high, therefore c) he caused the outbreak. You can find YouTube videos to back up every lunatic idea in existence. What we need is evidence. You can bet that any eventual solution to this thing is science-based and data-driven, as will be any efforts to mitigate risk in the meantime. Perhaps attribution of cause should be approached in a similar manner? Instead of alternating-caps-grade nonsense.
There is
zero evidence that it is man-made. To suggest without evidence that it is man-made is irresponsible, and diverts attention away from the need to understand the specific natural cause and the transmission mechanism by which it has caused the current global pandemic. If we don't understand it, then we can't prevent things like this (or worse) occurring in future.
In fact there is
very strong scientific evidence that it is a natural disease. Conspiracy theorists should have a read of
this paper.
“By comparing the available genome sequence data for known coronavirus strains, we can firmly determine that SARS-CoV-2 originated through natural processes,” said Kristian Andersen, PhD, an associate professor of immunology and microbiology at Scripps Research and corresponding author on the paper.
Evidence for natural evolution
The scientists found that the RBD portion of the SARS-CoV-2 spike proteins had evolved to effectively target a molecular feature on the outside of human cells called ACE2, a receptor involved in regulating blood pressure. The SARS-CoV-2 spike protein was so effective at binding the human cells, in fact, that the scientists concluded it was the result of natural selection and not the product of genetic engineering.
This evidence for natural evolution was supported by data on SARS-CoV-2’s backbone – its overall molecular structure. If someone were seeking to engineer a new coronavirus as a pathogen, they would have constructed it from the backbone of a virus known to cause illness. But the scientists found that the SARS-CoV-2 backbone differed substantially from those of already known coronaviruses and mostly resembled related viruses found in bats and pangolins.
“These two features of the virus, the mutations in the RBD portion of the spike protein and its distinct backbone, rules out laboratory manipulation as a potential origin for SARS-CoV-2” said Andersen.
Josie Golding, PhD, epidemics lead at UK-based Wellcome Trust, said the findings by Andersen and his colleagues are “crucially important to bring an evidence-based view to the rumors that have been circulating about the origins of the virus (SARS-CoV-2) causing COVID-19.”
“They conclude that the virus is the product of natural evolution,” Golding adds, “ending any speculation about deliberate genetic engineering.”
The overwhelming likelihood is that it originated in bats and came to humans via an intermediary species. See quote below (from the link above). There is little scientific doubt as to this origin. Truth is revealed as such because it is backed up by data and evidence. The only real area of debate is whether the virus reached its current mutation before or after the initial transmission to humans.
Possible origins of the virus
Based on their genomic sequencing analysis, Andersen and his collaborators concluded that the most likely origins for SARS-CoV-2 followed one of two possible scenarios.
In one scenario, the virus evolved to its current pathogenic state through natural selection in a non-human host and then jumped to humans. This is how previous coronavirus outbreaks have emerged, with humans contracting the virus after direct exposure to civets (SARS) and camels (MERS). The researchers proposed bats as the most likely reservoir for SARS-CoV-2 as it is very similar to a bat coronavirus. There are no documented cases of direct bat-human transmission, however, suggesting that an intermediate host was likely involved between bats and humans.
In this scenario, both of the distinctive features of SARS-CoV-2’s spike protein—the RBD portion that binds to cells and the cleavage site that opens the virus up—would have evolved to their current state prior to entering humans. In this case, the current epidemic would probably have emerged rapidly as soon as humans were infected, as the virus would have already evolved the features that make it pathogenic and able to spread between people.
In the other proposed scenario, a non-pathogenic version of the virus jumped from an animal host into humans and then evolved to its current pathogenic state within the human population. For instance, some coronaviruses from pangolins, armadillo-like mammals found in Asia and Africa, have an RBD structure very similar to that of SARS-CoV-2. A coronavirus from a pangolin could possibly have been transmitted to a human, either directly or through an intermediary host such as civets or ferrets.
Then the other distinct spike protein characteristic of SARS-CoV-2, the cleavage site, could have evolved within a human host, possibly via limited undetected circulation in the human population prior to the beginning of the epidemic. The researchers found that the SARS-CoV-2 cleavage site, appears similar to the cleavage sites of strains of bird flu that has been shown to transmit easily between people. SARS-CoV-2 could have evolved such a virulent cleavage site in human cells and soon kicked off the current epidemic, as the coronavirus would possibly have become far more capable of spreading between people.
