The only disadvantage of Donaire's age is his stamina not his speed nor power, no one can doubt that because his oxygen tank slowly depletes as he grow older and so does the other boxers. What he lacks is the stamina to go all the way until round 12 without getting so weary because Inoue can still dance in the late rounds and that's the time where Inoue will summon all his strengths to take down the aging Donaire, I agreee Donaire's only choice is to be more aggressive and more accurate in the punches in the early rounds.
It is such a shame that we do not get to see Donaire fighting at his prime otherwise this fight could have a great chance of becoming the fight of the year, but still it is nice that we get to see the fight happen at all, and without a doubt the biggest obstacle for Donaire to win this fight will be his stamina, Donaire needs to accumulate enough advantage over Inoue during the first 9 rounds of the fight and if he cannot do it then Inoue will most likely win the fight by taking advantage of his superior stamina.
We can't do about that already as it was already in the past, the important thing is that Donaire is still improving to be the best despite of his age. I'm not seeing Donaire's age as an disadvantage because he still capable to knockout someone who will get caught in his punches.
Both have already have the knowledge on what needed to be improved and I think we will see a different version of them. As for power and speed, they don't have that much gap but the difference is that Inoue can take the punches while faking that he didn't felt anything of it and ofcourse their stamina level.
Yes, both will adjust. Even Inoue beats Donaire from their last match for sure he manages to watch the latest win of Donaire.
And his camp will adjust to what possible strategy Donaire may use against them, in terms of Donaire, he already tastes the killer punches
of Inoue and with that, he needs to save up his stamina. Age may not be the problem, as looking with that last fight, Donaire still has
the kind of movement that can stand and possible in beating even the furious Inoue.