I think Murray can still give a good fight, although Tsitsipas might win in 2 sets, but that handicap? not sure if he can cover it. So I will skip this match, there are a lot of games that it worth to bet to give us a good returns.
Did not check US Open draws yet, I like to leave it until last minutes before matches start when counter handicaps offer biggest value. Usually odds on favorites drop a lot and consequently give much more value for my bets on underdogs to cover the spread.